Acetylcholinesterase Inhibition Activity of Portuguese Thymus Species Essential Oils

作者：Dandlen Susana A; Miguel Maria G^*; Duarte Joao; Faleiro Maria L; Sousa Maria J; Lima Ana S; Figueiredo Ana C; Barroso Jose G; Pedro Luis G

来源：Journal of Essential Oil Bearing Plants, 2011, 14(2): 140-150.

DOI：10.1080/0972060X.2011.10643914

• Acetylcholinesterase inhibition
• Thymus
• Essential oils
• Carvacrol
• Borneol
• 1,8-Cineole

Thymus species are commonly known in Portugal as thyme and they are currently used as culinary herbs, as well as for ornamental, aromatizing and traditional medicinal purposes. The essential oils isolated from the Portuguese Thymus caespititius (Sect. Micantes), T. camphoratus and T. capitellatus (Sect. Thymus, Subsect. Thymastra), T. carnosus, T. zygis subsp. sylvestris and T. zygis subsp. zygis (Sect. Thymus, Subsect. Thymus) were evaluated for acetylcholinesterase inhibition capacity. A great variability in activity was detected in the assayed essential oils, even among oils isolated from a same species with different geographical origins, such as T. caespititius. T. zygis subsp. zygis essential oil showed the strongest acetylcholinesterase inhibition capacity with an IC50 = 1.1 mu g/ml.

• 出版日期2011