Applications of IMAT in cervical esophageal cancer radiotherapy: a comparison with fixed-field IMRT in dosimetry and implementation

作者：Yin Yong; Chen Jinhu; Xing Ligang; Dong Xiaoling; Liu Tonghai; Lu Jie; Yu Jinming^*

来源：Journal of Applied Clinical Medical Physics, 2011, 12(2): 48-57.

• intensity-modulated radiotherapy
• intensity-modulated arc radiotherapy
• dosimetry
• esophageal neoplasms

This study aimed to compare fixed-field, intensity-modulated radiotherapy (f-IMRT) with intensity-modulated arc therapy (IMAT) treatment plans in dosimetry and practical application for cervical esophageal carcinoma. For ten cervical esophageal carcinoma cases, f-IMRT plan (seven fixed-fields) and two IMAT plans, namely RA (coplanar 360 degrees arcs) and RAx (coplanar 360 degrees arcs without sectors from 80 degrees to 110 degrees, and 250 degrees to 280 degrees), were generated. DVHs were adopted for the statistics of above parameters, as well as conformal index (CI), homogeneity index (HI), dose-volumetric parameters of normal tissues, total accelerator output MUs and total treatment time. There were differences between RAx and f-IMRT, as well as RA in PTV parameters such as HI, V(95%) and V(110%), but not in CI. RAx reduced lung V(5) from (50.9% +/- 9.8% in f-IMRT and (51.4% +/- 10.8% in RA to (49.3% +/- 10.4% in RAx (p < 0.05). However, lung V(30), V(40), V(50) and MLD increased in RAx. There was no difference in the mean heart dose in three plans. Total MU was reduced from 1174.8 +/- 144.6 in f-IMRT to 803.8 +/- 122.2 in RA and 736.2 +/- 186.9 in RAx(p < 0.05). Compared with f-IMRT, IMAT reduced low dose volumes of lung and total MU on the basis of meeting clinical requirements.

• 出版日期2011
• 单位山东大学