Aromatic oligoamides with increased backbone flexibility: improved synthetic efficiencies, solvent-dependent folding and cooperative conformational transitions

作者：Liu, Rui; Connor, Alan L.; Al-mkhaizim, Fayez Y.; Gong, Bing^*

来源：New Journal of Chemistry, 2015, 39(5): 3217-3220.

DOI：10.1039/c4nj01820f

• HYDROGEN-BONDING INTERACTIONS
• HELICAL SECONDARY STRUCTURE
• SELF-ORGANIZATION
• BETA-PEPTIDES
• AMINO-ACID
• FOLDAMERS
• OLIGOMERS
• FAMILY
• POLYPEPTOIDS
• AGGREGATION

Aromatic oligoamides 2a, 2b, and 2c of increasing chain lengths were prepared and further characterized for their folding behaviour. These oligomers were derived by relaxing the backbone-constraint of a series of oligoamides that fold into well-defined conformations. With their backbones of increased flexibility, the resultant 2a-c were found to form with considerably improved efficiencies, and undergo highly cooperative folding that depends on chain length, solvents, and temperature.

• 出版日期2015
• 单位北京师范大学