A copper-mediated cross-coupling approach for the synthesis of 3-heteroaryl quinolone and related analogues

作者:Shin Sanghye; Kim Yechan; Kim Kiho; Hong Sungwoo*
来源:Organic and Biomolecular Chemistry, 2014, 12(30): 5719-5726.
DOI:10.1039/c4ob00939h

摘要

An efficient and practical method for the direct cross-coupling between quinolones and a range of azoles was developed via copper-mediated C-H functionalization. This synthetic strategy provides a convenient access to a variety of C3-heteroaryl quinolones, quinolinone, nalidixic acid, uracil, pyridone and chromone derivatives, which are prominent structural motifs in many biologically active compounds.

  • 出版日期2014-8-14