Preparation of phenolic compounds through catalyst-free ipso-hydroxylation of arylboronic acids

作者：Gohain Mukut; du Plessis Maretha; van Tonder Johannes H; Bezuidenhoudt Barend C B^*

来源：Tetrahedron Letters, 2014, 55(13): 2082-2084.

DOI：10.1016/j.tetlet.2014.02.048

• Polyethylene glycol
• Hydrogen peroxide
• Arylboronic acid
• Hydroxylation
• Catalyst-free
• Phenolic compounds

A novel method for the preparation of phenolic compounds through ipso-hydroxylation of the corresponding widely available arylboronic acid precursors is described. Through application of a novel PEG400-H2O2 reactant system, a variety of substituted phenols and other aromatic analogues have been prepared in excellent yields at room temperature in the absence of any catalyst.

• 出版日期2014-3-26