Neurocognitive Consequences of HIV Infection in Older Adults: An Evaluation of the "Cortical" Hypothesis

作者：Scott J Cobb^*; Woods Steven Paul; Carey Catherine L; Weber Erica; Bondi Mark W; Grant Igor

来源：AIDS and Behavior, 2011, 15(6): 1187-1196.

DOI：10.1007/s10461-010-9815-8

• Human immunodeficiency virus
• Aging
• Cognition
• Neuropsychological tests
• Episodic memory

The incidence and prevalence of older adults living with HIV infection is increasing. Recent reports of increased neuropathologic and metabolic alterations in older HIV+ samples, including increased cortical beta-amyloid, have led some researchers to suggest that aging with HIV may produce a neuropsychological profile akin to that which is observed in "cortical" dementias (e.g., impairment in memory consolidation). To evaluate this possibility, we examined four groups classified by HIV serostatus and age (i.e., younger a parts per thousand currency sign40 years and older a parts per thousand yen50 years): (1) Younger HIV- (n = 24); (2) Younger HIV+ (n = 24); (3) Older HIV- (n = 20); and (4) Older HIV+ (n = 48). Main effects of aging were observed on episodic learning and memory, executive functions, and visuoconstruction, and main effects of HIV were observed on measures of verbal learning and memory. The interaction of age and HIV was observed on a measure of verbal recognition memory, which post hoc analyses showed to be exclusively attributed to the superior performance of the younger HIV seronegative group. Thus, in this sample of older HIV-infected individuals, the combined effects of HIV and aging do not appear to result in a "cortical" pattern of cognitive deficits.

• 出版日期2011-8