Systemic and brain metabolic dysfunction as a new paradigm for approaching alzheimer's dementia

作者：Giordano Vincenzo; Peluso Gianfranco; Iannuccelli Maurizio; Benatti Paola; Nicolai Raffaella; Calvani Menotti^*

来源：Neurochemical Research, 2007, 32(4-5): 555-567.

DOI：10.1007/s11064-006-9125-8

• Alzheimer's disease
• cholesterol
• insulin
• leptin
• ghrelin
• adiponectin

Since its definition Alzheimer's disease has been at the centre of consideration for neurologists, psychiatrists, and pathologists. With John P. Blass it has been disclosed a different approach Alzheimer's disease neurodegeneration understanding not only by the means of neurochemistry but also biochemistry opening new scenarios in the direction of a metabolic system degeneration. Nowadays, the understanding of the role of cholesterol, insulin, and adipokines among the others in Alzheimer's disease etiopathogenesis is clarifying approaches valuable not only in preventing the disease but also for its therapy.

• 出版日期2007-4