Regioselective Preferential Nucleophilic Addition of N-Heterocycles onto Haloarylalkynes over N-Arylation of Aryl Halides

作者：Joshi Megha; Tiwari Rakesh; Verma Akhilesh Kumar^*

来源：Organic Letters, 2012, 14(4): 1106-1109.

DOI：10.1021/ol203491p

The study of preferential addition of heterocyclic amines onto halo-substituted arylalkynes over N-arylation under various catalytic conditions is described. The present work supports and confirms the mechanistic pathway of our recent work on the tandem synthesis of indolo- and pyrrolo-[2,1-a]isoquinolines via hydroamination followed by oxidative addition and not vice versa.

• 出版日期2012-2-17