Architecture of the Spliceosome

作者：van der Feltz Clarisse; Anthony Kelsey; Brilot Axel; Krummel Daniel A Pomeranz^*

来源：Biochemistry, 2012, 51(16): 3321-3333.

DOI：10.1021/bi201215r

Precursor-mRNA splicing is catalyzed by an extraordinarily large and highly dynamic macromolecular assemblage termed the spliceosome. Detailed biochemical and structural study of the spliceosome presents a formidable challenge, but there has recently been significant progress made on this front highlighted by the crystal structure of a 10-subunit human U1 snRNP. This review provides an overview of our current understanding of the architecture of the spliceosome and the RNA-protein complexes integral to its function, the U snRNPs.

• 出版日期2012-4-24