A practical fluorous benzylidene acetal protecting group for a quick synthesis of disaccharides

作者：Kojima Masaru; Nakamura Yutaka; Takeuchi Seiji^*

来源：Tetrahedron Letters, 2007, 48(25): 4431-4436.

DOI：10.1016/j.tetlet.2007.04.106

• benzylidene acetal group
• regioselective reduction
• oligosacchrides
• fluorous solid phase extraction

A new fluorous benzylidene acetal protecting group was regio selectively introduced into carbohydrates, deprotected under acidic conditions, and reused. Oligosaccharides were synthesized via regioselective conversion of the fluorous acetal group to the benzyl group by traditional reaction conditions. The fluorous compounds were easily separated from non-fluorous by-products by fluorous solid phase extraction.

• 出版日期2007-6-18