A magnetic nanogel based on O-carboxymethylchitosan for antitumor drug delivery: synthesis, characterization and in vitro drug release

作者：Demarchi Carla Albetina; Debrassi Aline; Buzzi Fatima de Campos; Correa Rogerio; Cechinel Filho Valdir; Rodrigues Clovis Antonio^*; Nedelko Nataliya; Demchenko Pavlo; Slawska Waniewska Anna; Dluzewski Piotr; Greneche Jean Marc

来源：Soft Matter, 2014, 10(19): 3441-3450.

DOI：10.1039/c3sm53157k

This paper studied the synthesis, characterization and use of the magnetic chitosan nanogel for carrying meleimidic compounds. The hydrogel polymer was prepared using O-carboxymethylchitosan, which was crosslinked with epichlorohydrin for subsequent incorporation of iron oxide magnetic nanoparticles. The characterization revealed that the magnetic material comprises about 10% of the hydrogel. This material is comprised of magnetite and maghemite and exhibits ferro-ferrimagnetic behavior. The average particle size is 4.2 nm. There was high incorporation efficiency of maleimides in the magnetic nanogel. The release was of sustained character and there was a greater release when an external magnetic field was applied. The mathematical model that best explained the process of drug release by the magnetic hydrogel was that of Peppas-Sahlin. The magnetic nanogel proved to be an excellent candidate for use in drug-delivery systems.

• 出版日期2014