A novel and simply calculated nutritional index serves as a useful prognostic indicator in patients with coronary artery disease

作者：Doi Shinichiro; Iwata Hiroshi^*; Wada Hideki; Funamizu Takehiro; Shitara Jun; Endo Hirohisa; Naito Ryo; Konishi Hirokazu; Tsuboi Shuta; Ogita Manabu; Dohi Tomotaka; Kasai Takatoshi; Okazaki Shinya; Isoda Kikuo; Miyauchi Katsumi; Daida Hiroyuki

来源：International Journal of Cardiology, 2018, 262: 92-98.

DOI：10.1016/j.ijcard.2018.02.039

• Nutritional index
• Prognosis
• Coronary artery disease

Objective: No nutritional index has been firmly established yet in patients with coronary artery disease (CAD). In this study, we propose a simple to calculate nutritional indicator in patients who underwent percutaneous coronary intervention (PCI) by using parameters routinely measured in CAD and evaluated its prognostic implication.
Methods: This study is a retrospective observational analysis of a prospective database. The subjects were consecutive 3567 patients underwent their first PCI between 2000 and 2013 at Juntendo University Hospital in Tokyo. The median of the follow-up period was 6.3 years (range: 0-13.6 years). The novel nutritional index was calculated by the formula; Triglycerides (TG) x Total Cholesterol (TC) x Body Weight (BW) Index (TCBI)= TG x TC x BW/1000 (TG and TC: mg/dl, and BW: kg).
Results: The Spearman non-parametric correlation coefficient between TCBI and the most often used conventional nutritional index, Geriatric Nutritional Risk Index (GNRI), was 0.355, indicating modest correlation. Moreover, Unadjusted Kaplan-Meier analysis showed higher all-cause mortality, cardiovascular mortality, and cancer mortality in patients with low TCBI. Consistently, elevation of TCBI was associated with reduced all-cause (hazard ratio: 0.86, 95% CI: 0.77-0.96, p < 0.001), cardiovascular (0.78, 0.66-0.92, p= 0.003), and cancer mortality (0.76, 0.58-0.99, p= 0.041) in patients after PCI by multivariate Cox proportional hazard analyses.
Conclusion: TCBI, a novel and easy to calculate nutrition index, is a useful prognostic indicator in patients with CAD.

• 出版日期2018-7-1