Microbiota-host symbiosis in the pathophysiology and treatment of irritable bowel, irritable eye and irritable mind syndrome

作者：Feher Janos^*; Kovacs Illes; Elena Pacella; Radak Zsolt

来源：ORVOSI HETILAP, 2014, 155(37): 1454-1460.

DOI：10.1556/OH.2014.29987

• microbiota
• symbiosis
• Lactobacillus acidophilus
• Bifidobacterium longum
• lysate
• physical activity

Accumulating clinical evidence supports co-morbidity of irritable bowel, irritable eye and irritable mind symptoms. Furthermore, perturbation of the microbiota-host symbiosis (dysbiosis) is considered a common pathogenic mechanism connecting gastrointestinal, ocular and neuropsychiatric symptoms. Consequently, maintaining or restoring microbiota-host symbiosis represents a new approach to treat these symptoms or to prevent their relapses. Current treatment approach assigned a primary role to live probiotics alone or in combination with prebiotics to enhance colonization of beneficial bacteria and to strengthen the symbiosis. However, several papers showed major benefits of heat-killed probiotics as compared to their live counterparts on both intestinal and systemic symptoms. Recently, in addition to killing probiotics, in a proof of concept study lysates (fragments) of probiotics in combination with vitamins A, B, D and omega 3 fatty acids were successfully tested. These findings suggested a conceptual change in the approach addressed to both the microbiota and host as targets for intervention.

• 出版日期2014-9