Antileishmanial, antiplasmodial and cytotoxic activities of 12,16-dideoxy aegyptinone B from Zhumeria majdae rech.f. & wendelbo

作者：Moein Mahmood Reza; Pawar Rahul S; Khan Shabana I; Tekwani Babu L; Khan Ikhlas A^*

来源：Phytotherapy Research, 2008, 22(3): 283-285.

DOI：10.1002/ptr.2305

• Zhumeria majdae
• 12,16-dideoxy aegyptinone B
• Labiateae
• antileishmanial
• antiplasmodial
• cytotoxicity

The ethanol extract of Zhumeria majdae showed potent antileishmanial and antiplasmodial activity in vitro. Bioactivity guided fractionation of the extract led to the isolation of 12,16-dideoxy aegyptinone B (1). This compound exhibited potent in vitro antileishmanial activity with an IC50 of 0.75 mu g/mL and a strong antiplasmodial activity with IC50 values of 1.3 and 1.4 mu g/mL against chloroquine sensitive and resistant strains, respectively. This compound was further found to have mild cytotoxicity towards cancer cell lines.

• 出版日期2008-3