Beyond azide-alkyne click reaction: easy access to F-18-labelled compounds via nitrile oxide cycloadditions

作者：Zlatopolskiy Boris D; Kandler Rene; Kobus Diana; Mottaghy Felix M; Neumaier Bernd^*

来源：Chemical Communications, 2012, 48(57): 7134-7136.

DOI：10.1039/c2cc31335a

Radiofluorinated 4-fluorobenzonitrile oxide and N-hydroxy-4-fluorobenzimidoyl chloride rapidly react with different alkenes and alkynes under mild conditions. These cycloadditions are suitable for the preparation of low-molecular weight radiopharmaceuticals and, in a strain-promoted variant, can enable easy labelling of sensitive biopolymers.

• 出版日期2012