Stereoselective synthesis and rearrangement-fragmentation of arylidene N-alkoxydiketopiperazines

作者:Liu Shouxin*; Mu Yun; Han Jianrong; Zhen Xiaoli; Yang Yihua; Tian Xia; Whiting Andrew
来源:Organic and Biomolecular Chemistry, 2011, 9(21): 7476-7481.
DOI:10.1039/c1ob05722g

摘要

A stereoselective synthesis of arylidene N-alkoxydiketopiperazines via oxime-ether formation and intramolecular acylation is described, followed by an acid-catalysed rearrangement-fragmentation to give novel diketopiperazine hemiaminal derivatives with useful bioactivity against certain tumour cell lines.

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