Novel Biodegradable pH/Thermosensitive Hydrogels: Part 1. Preparation and Characterization

作者：Dong, Kai; Xu, Wei; You, Cui Yu; Xing, Jian Feng; Zhang, Ye Ji; Gao, Yang; Wang, Ke^*

来源：International Journal of Polymeric Materials and Polymeric Biomaterials, 2013, 62(14): 726-732.

DOI：10.1080/00914037.2013.769233

• Biodegradable
• degradation
• pH/thermosensitive
• swelling/deswelling

A series of biodegradable and pH/thermosensitive hydrogels based on monomethoxyl poly(ethylene glycol) (MPEG), poly(E-caprolactone) (PCL), methylacrylic acid (MAA), and N-Isopropylacrylamide (NIPAAm) were prepared by UV-initiated free radical polymerization method. Swelling behavior and hydrolytic degradable behavior in aqueous medium with different pH values and pH/thermosensitivity of the hydrogels were studied in detail. The prepared biodegradable pH/thermo-sensitive hydrogels based on PCL, MPEG, MAA, and NIPAAm may have great potential application in smart drug delivery system.

• 出版日期2013-6-28
• 单位西安交通大学