科研之友
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摘要
Introduction: Visual performance impairment after hypoxia is well recognized in military and civilian aviation. The aims of this study were: 1) to assess oculometric features such as blink metrics, pupillary dynamics, fixations, and saccades as cognitive indicators of early signs of hypoxia; and 2) to analyze the impact of different hypoxic conditions ['' hypoxic hypoxia '' (HH) and '' socapnic hypoxia '' (IH)] on specified oculometrics during mental workloads. Methods: Oculometric data were collected on 25 subjects under 3 conditions: normoxia, HH (8% O-2 + balance N-2), and IH (7% O-2 + 5% CO2 + balance N-2). The mental workload task consisted of reading aloud linear arrays of numbers after exposure to gas mixtures. Results: Blink rates were significantly increased under hypoxic conditions (by +100.7% in HH and by +92.8% in IH compared to normoxia). A faster recovery of blink rate was observed in transitioning from IH (23.6% vs. 76.3%) to normoxia. The percentage change in pupil size fluctuation was increased under HH more than under IH (29% vs. 4.4%). Under HH average fixation time and target area size were significantly higher than under IH. Total saccadic times under hypoxic conditions were significantly increased compared with normoxia. Conclusions: These results suggest that oculometric changes are indicators of hypoxia, which can be monitored using compact, portable, noninvasive eye-tracking devices in a cockpit analogous environment to detect hypoxia-induced physiological changes in aircrew. Comparative results between HH and IH support the potential role of carbon dioxide in augmenting cerebral perfusion and hence improved tissue oxygen delivery.
- 出版日期2014-7
