Inward Rotating Spiral Waves in Glycolysis

作者:Straube Ronny*; Vermeer Satenik; Nicola Ernesto M; Mair Thomas
来源:Biophysical Journal, 2010, 99(1): L4-L6.
DOI:10.1016/j.bpj.2010.04.018

摘要

We report on the first observation of inward rotating spiral waves (antispirals) in a biochemical reaction-diffusion system. Experiments are performed with extracts from yeast cells in an open spatial reactor. By increasing the protein concentration of the extract we observe a transition from outward to inward propagating waves of glycolytic activity. Numerical simulations with an allosteric model for the phosphofructokinase can reproduce these inward propagating waves over a wide range of parameters if the octameric structure of yeast phosphofructokinase is taken into account.

  • 出版日期2010-7-7