Associations Between Bone Mineral Density, Grip Strength, and Lead Body Burden in Older Men

作者：Khalil Naila^*; Faulkner Kimberly A; Greenspan Susan L; Cauley Jane A

来源：Journal of the American Geriatrics Society, 2014, 62(1): 141-146.

DOI：10.1111/jgs.12603

• lead
• elderly
• men
• bone
• grip strength
• cognition
• physical function

ObjectivesTo study the association between blood lead concentration (BPb) and bone mineral density (BMD), physical function, and cognitive function in noninstitutionalized community-dwelling older men. %26lt;br%26gt;DesignCross-sectional study. %26lt;br%26gt;SettingUniversity of Pittsburgh clinic, Pittsburgh, Pennsylvania. %26lt;br%26gt;ParticipantsNon-Hispanic Caucasian men aged 65 and older (N=445) recruited as a subset of a prospective cohort for the Osteoporotic Fractures in Men Study. %26lt;br%26gt;MeasurementsBPb was measured in 2007/08. From 2007 to 2009, BMD (g/cm(2)) was measured using dual-energy X-ray absorptiometry. At the same time, physical performance was measured using five tests: grip strength, leg extension power, walking speed, narrow-walk pace, and chair stands. Cognitive performance was assessed using the modified Mini-Mental State Examination and the Trail-Making Test Part B. Participants were categorized into quartiles of BPb. Multivariate regression analysis was used to evaluate the independent relationship between BPb, BMD, and cognitive and physical function. %26lt;br%26gt;ResultsMean BPbstandard deviation was 2.25 +/- 1.20g/dL (median 2g/dL, range 1-10g/dL). In multivariate-adjusted models, men in higher BPb quartiles had lower BMD at femoral neck and total hip (P-trend%26lt;.001 for both). Men with higher BPb had lower age-adjusted score for grip strength (P-trend%26lt;.001), although this association was not significant in multivariate-adjusted models (P-trend%26lt;.15). BPb was not associated with lumbar spine BMD, cognition, leg extension power, walking speed, narrow-walk pace, or chair stands. %26lt;br%26gt;ConclusionEnvironmental lead exposure may adversely affect bone health in older men. These findings support consideration of environmental exposure in age-associated bone fragility.

• 出版日期2014-1