Apelin and Relaxin Plasma Levels in Young Healthy Offspring of Patients With Essential Hypertension

作者：Papadopoulos Dimitris P^*; Makris Thomas; Perrea Despina; Zerva Kannelina; Tsioufis Costas; Faselis Charles; Papademetriou Vasilios

来源：Journal of Clinical Hypertension, 2014, 16(3): 198-201.

DOI：10.1111/jch.12260

Epidemiologic studies have shown that healthy offspring of hypertensive patients exhibit many features of the metabolic syndrome, such as hyperinsulinemia, insulin resistance, and lipid disorders, while hypoapelinemia and hyporelaxinemia may contribute to vascular damage that accelerates atherogenesis. The aim of this study was to determine apelin and relaxin plasma levels in the healthy offspring of hypertensive patients and to compare the findings with those of healthy offspring of healthy parents, matched for age, sex, and body mass index (BMI). Forty-six (24 men and 22 women) healthy offspring of hypertensive patients, mean age 18 +/- 3years and BMI 22.4 +/- 1.4kg/m(2) (group A), and 50 healthy offspring of healthy parents (28 men and 22 women), mean age 18 +/- 3.2years and BMI 22.6 +/- 1.7kg/m(2) (group B), were studied. The apelin and relaxin plasma levels (enzyme-linked immunosorbent assay method) were determined in the study population. The two groups were matched for age, sex, and BMI. Plasma apelin levels (6 +/- 3 vs 105pg/mL, P<.001) and relaxin plasma levels (20 +/- 7 vs 29 +/- 8pg/mL, P<.001) were significantly lower in group A compared with group B, respectively. Our findings suggest that healthy offspring of healthy parents have significantly lower plasma apelin and relaxin levels. This group of individuals needs closer follow-up and further examination.

• 出版日期2014-3