MRI-guided celiac plexus neurolysis for pancreatic cancer pain: Efficacy and safety

作者：Liu, Shangang; Fu, Weiwei; Liu, Zengjun; Liu, Ming; Ren, Ruimei; Zhai, Huaxu; Li, Chengli^*

来源：Journal of Magnetic Resonance Imaging, 2016, 44(4): 923-928.

DOI：10.1002/jmri.25246

• interventional MRI
• celiac plexus neurolysis
• ethanol
• pancreatic cancer
• pain

PurposeTo prospectively determine the efficacy and safety of magnetic resonance imaging (MRI)-guided celiac plexus neurolysis (CPN) for pancreatic cancer pain. @@@ Materials and MethodsIn all, 39 patients with pancreatic cancer underwent 0.23T MRI-guided CPN with ethanol via the posterior approach. The pain relief, the opioid intake, and pain interference with appetite, sleep, and communication in patients were assessed after CPN during a 4-month follow-up period. The complications were also evaluated during or after CPN. @@@ ResultsCPN procedures were successfully completed for all patients. Minor complications included diarrhea (9 of 39; 23.1%), orthostatic hypotension (14 of 39; 35.9%), and local backache (20 of 39; 51.3%). No major complication occurred. Pain relief was observed in 36 (92.3%), in 15 (40.5%), and in 11 (35.5%) patients at 1-, 2-, and 3-month visits, respectively. The median duration of pain relief was 2.9 months (95% confidence interval [CI], 2.4-3.4). The opioid intake significantly decreased at the 1-, 2-, and 3-month visits (P < 0.001, < 0.001, = 0.001 respectively), and there was significant improvement in sleep at the 1-, 2-, and 3-month visits (P < 0.001, < 0.001, = 0.001 respectively), and appetite and communication were significantly improved at the 1- and 2-month visits (all P < 0.001); all compared with baseline. @@@ ConclusionMRI-guided CPN appears to be an effective and minimally invasive procedure for palliative pain management of pancreatic cancer. J. MAGN. RESON. IMAGING 2016;44:923-928.

• 出版日期2016-10
• 单位山东大学; 山东省医学影像学研究所