INFLUENCE OF MUSCLE ACTIVITY ON BRAIN OXYGENATION DURING VERBAL FLUENCY ASSESSED WITH FUNCTIONAL NEAR-INFRARED SPECTROSCOPY

作者：Schecklmann M^*; Ehlis A C; Plichta M M; Fallgatter A J

来源：Neuroscience, 2010, 171(2): 434-442.

DOI：10.1016/j.neuroscience.2010.08.072

• functional near infrared spectroscopy
• fNIRS temporalis muscle
• electromyography
• verbal fluency
• fronto temporal oxygenation

A large part of the literature of functional near infrared spectroscopy (fNIRS) deals with overt verbal fluency It has been claimed that fNIRS has a low susceptibility to movement related artefacts as for example, associated with overt speech However so far, no study has investigated this assumption in an experimental design Therefore, we examined a group of 16 healthy subjects during performance of two verbal fluency tasks (experiment 1 phonological fluency, experiment 2 semantical fluency, paced answers, pronouncing vs writing) We measured changes of oxygenated (O(2)Hb) and deoxygenated haemoglobin (HHb) over fronto temporal (brain) areas via fNIRS while temporalis muscle activity was simultaneously assessed by means of electromyography (EMG) Statistical analyses indicated comparable word production, higher increases of O(2)Hb and higher decreases of HHb over fronto temporal areas during word fluency in contrast to the control task weekday reciting This fNIRS pattern indicates fluency related activation and was found for pronouncing and for writing in both experiments Regarding the EMG data fluency related activity was only found for pronouncing, not for writing Thus, muscle activity cannot account for fluency related fNIRS activity during writing Additionally, correlation analyses showed no systematic associations of fNIRS and EMG signals In conclusion we found arguments that fNIRS actually allows for the measurement of brain activity over fronto temporal areas during verbal fluency Nonetheless, further studies should evaluate more direct associations between fNIRS a

• 出版日期2010-12-1