Action of a Nitric Oxide Donor Dinitrosyl Complex of Iron With Glutathione on the Circulation in Rats and Monkeys

作者：Lakomkin V L^*; Timoshin A A; Orlova Ts R; Gubkina S A; Storozhilova A N; Gvozdik T E; Dobrovolsky A B; Ruuge E K; Vanin A F; Kapelko V I; Lapin B A; Chazov E I

来源：Kardiologiya, 2009, 49(5): 53-60.

• nitric oxide donors
• hemodynamics
• normotensive rats
• spontaneously hypertensive (SHR) rats
• antihypertensive agents

We studied action of a nitric oxide donor, dinitrosyl complex of iron (DNIC) with glutathione as a ligand on the hemodynamics of normotensive Wistar rats, spontaneously hypertensive rats (SHR), and monkeys. intravenous DNIC introduction (2-120 mg/kg) rendered fast (1-2 min) hypotensive effect combined with increased heart rate by 10-25%. Second phase of the effect in Wistar rats was characterized by slowed recovery of arterial pressure and heart rate up to initial level. A gradual DNIC breakdown in blood occurred during this period associated with increased NO accumulation in organs with intensive oxidative metabolism (liver, heart, and kidney). Duration of hypotensive effect in all animals depended on dose, this dependence was most expressed in SHR.

• 出版日期2009