Actin shapes the autophagosome

作者:Holland Petter*; Simonsen Anne
来源:Nature Cell Biology, 2015, 17(9): 1094-1096.
DOI:10.1038/ncb3224

摘要

Compared with most intracellular vesicles, the autophagosome is formed by an unusual event of vesicle budding involving an elusive sequence of membrane expansions that ends with a double membrane vesicle. It is now shown that actin polymerization inside the forming autophagosome is a driving force for the expansion and assembly of a functional autophagosome.

  • 出版日期2015-9