Acute-phase CD4( ) T-cell proliferation and CD152 upregulation predict set-point virus replication in vaccinated simian-human immunodeficiency virus strain 89.6p-infected macaques

作者：Koopman Gerrit^*; Mortier Daniella; Hofman Sam; Koutsoukos Marguerite; Bogers Willy M J M; Wahren Britta; Voss Gerald; Heeney Jonathan L

来源：Journal of General Virology, 2009, 90(4): 915-926.

DOI：10.1099/vir.2008.006148-0

Human immunodeficiency virus (HIV) infection in humans and simian immunodeficiency virus (SIV) infection in macaques are accompanied by a combined early loss of CCR5 (CD195)-expressing CD4( ) memory T cells, loss of T-helper function and T-cell hyperactivation, which have all been associated with development of high virus load and disease progression. Here, a cohort of vaccinated simian-human immunodeficiency virus strain 89.6p (SHIV89.6p)-infected rhesus macaques, where preferential depletion of these memory T-cell subsets does not take place and CD4( ) T cells are relatively well maintained, was used to study the role of hyperactivation as an independent factor in the establishment of set-point virus load. In the acute phase of the infection, a transient loss of CD4( ) T cells, as well as strong increases in expression of proliferation and activation markers on CD4( ) and CD8( ) T cells, together with CD152 expression on CD4( ) T cells, were observed. Peak expression levels of these markers on CD4( ) T cells, but not on CD8( ) T cells, were correlated with high virus replication in the chronic phase of the infection. In addition, the peak expression level of these markers was correlated inversely with acute-phase, but not chronic-phase, HIV/SIV-specific gamma interferon responses. These data highlight a central role for an acute but transient CD4 decrease, as well as CD4( ) T-cell activation, as independent factors for prediction of set-point levels of virus replication.

• 出版日期2009-4