AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4

作者：Garcia Anapatricia^*; Siddappa Nagadenahalli B; Li Qingsheng; Haase Ashley T; Paul Katherine; Stroud Fawn; Zhang Xiaodong; Fountain Jack A; Villinger Francois; Novembre Francis J; Else James G; Secor W Evan; Ruprecht Ruth M

来源：Journal of Medical Primatology, 2010, 39(5): 356-360.

DOI：10.1111/j.1600-0684.2010.00416.x

• neuroAIDS
• optic neuropathy
• R5 SHIV

A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4+ T cells to < 200 cells/mu l, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.

• 出版日期2010-10