Delivery of drug macromolecules from thermally responsive gel implants to the posterior eye

作者：Ninawe Pravin R; Hatziavramidis Dimitri^*; Parulekar Satish J

来源：Chemical Engineering Science, 2010, 65(18): 5170-5177.

DOI：10.1016/j.ces.2010.06.014

• Sustained delivery
• Drug macromolecule
• Thermally responsive gel
• Ocular drug delivery
• Sclera permeability
• Anti-VEGF agent

Therapeutic modalities for posterior-eye diseases involve mostly interventions through the anterior eye, which are difficult for physicians and patients alike. Currently, sustained drug delivery to the posterior eye is gaining importance. A study for sustained delivery of an anti-VEGF agent to the posterior eye from an implant, made of poly(N-isopropylacrylamide) (NIPAM) and placed episclerally, is presented. The thermally sensitive gel is modelled as a poroelastic material with a phase transition characterized by a lower critical solution temperature (LCST). The study utilizes compartments for various eye tissues, with individual compartments considered to be completely mixed and drug transport between compartments occurring by one-dimensional diffusion.

• 出版日期2010-9-15