Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover

作者：Mastushita Sakai Tomoko; White Grindley Erica; Samuelson Jessica; Seidel Chris; Si Kausik^*

来源：Proceedings of the National Academy of Sciences of the United States of America, 2010, 107(26): 11987-11992.

DOI：10.1073/pnas.1004433107

• protein synthesis
• synaptic plasticity
• memory

In the study of long-term memory, how memory persists is a fundamental and unresolved question. What are the molecular components of the long-lasting memory trace? Previous studies in Aplysia and Drosophila have found that a neuronal variant of a RNA-binding protein with a self-perpetuating prion-like property, cytoplasmic polyadenylation element binding protein, is required for the persistence of long-term synaptic facilitation in the snail and long-term memory in the fly. In this study, we have identified the mRNA targets of the Drosophila neuronal cytoplasmic polyadenylation element binding protein, Orb2. These Orb2 targets include genes involved in neuronal growth, synapse formation, and intriguingly, protein turnover. These targets suggest that the persistent form of the memory trace might be comprised of molecules that maintain a sustained, permissive environment for synaptic growth in an activated synapse.

• 出版日期2010-6-29
• 单位河北医科大学