Dephosphorylation of eIF2 alpha Mediated by the gamma(1)34.5 Protein of Herpes Simplex Virus 1 Facilitates Viral Neuroinvasion

作者：Verpooten Dustin; Feng Zongdi; Valyi Nagy Tibor; Ma Yijie; Jin Huali; Yan Zhipeng; Zhang Cuizhu; Cao Youjia; He Bin^*

来源：Journal of Virology, 2009, 83(23): 12626-12630.

DOI：10.1128/JVI.01431-09

The gamma(1)34.5 protein, a virulence factor of herpes simplex viruses, redirects protein phosphatase 1 to dephosphorylate the alpha subunit of translation initiation factor 2 (eIF2 alpha). Additionally, it inhibits the induction of antiviral genes by TANK-binding kinase 1. Nevertheless, its precise role in vivo remains to be established. Here we show that eIF2 alpha dephosphorylation by gamma(1)34.5 is crucial for viral neuroinvasion. (VE)-E-193 and (FL)-L-195 substitutions in gamma(1)34.5 abrogate viral replication in the eye and spread to the trigeminal ganglia and brain. Intriguingly, inhibition of antiviral gene induction by gamma(1)34.5 is not sufficient to exhibit viral virulence.

• 出版日期2009-12
• 单位南开大学