A study of the link between bone turnover markers and bone mineral density with inflammation and body mass in postmenopausal women with active rheumatoid arthritis

作者：Straburzynska Lupa Anna^*; Nowak Alicja; Romanowski Wojciech; Korman Pawel; Pilaczynska Szczesniak Lucja

来源：Journal of Bone and Mineral Metabolism, 2013, 31(2): 169-176.

DOI：10.1007/s00774-012-0400-2

• Bone
• Osteopontin
• Resistin
• Body mass index
• Rheumatoid arthritis

In this study, the levels of bone turnover markers (BTMs) and bone mineral density (BMD) were studied in relation to body mass and several inflammatory markers, in postmenopausal patients with rheumatoid arthritis (RA). Fifty-nine postmenopausal women with active RA (lean, overweight, obese) were studied. The femoral BMD and serum levels of BTMs: osteocalcin (OC) and collagen type I cross-linked C-telopeptide fragments (CTX), and osteopontin (OPN), resistin, high sensitivity C-reactive protein, interleukin-6, tumor necrosis factor (TNF)-alpha in these patients were measured. It has been noticed that obese women had significantly higher total femoral BMD and total T-score compared to the lean subjects (p a parts per thousand currency sign 0.01). The significant associations of BMD measures and CTX levels with body mass parameters (p a parts per thousand currency sign 0.01 and p < 0.05, respectively) were found. Values of neck BMD adjusted for BMI were inversely associated with concentrations of TNF-alpha (p < 0.05). Osteocalcin levels inversely correlated with resistin (p a parts per thousand currency sign 0.01) and CTX levels positively correlated with OPN (p a parts per thousand currency sign 0.01). There were found no associations between BTMs and BMD with other inflammatory indices. Inverse correlations between OPN levels and body mass (p < 0.05), waist circumference (p < 0.05), and duration of postmenopausal period (p a parts per thousand currency sign 0.01) were observed. Findings of the present study suggest that body mass and inflammatory markers, most of all OPN, resistin and TNF-alpha, play an important role in bone metabolism in postmenopausal women with active RA.

• 出版日期2013-3