A new synthesis of resveratrol

作者：Lara Ochoa Francisco^*; Sandoval Minero Leticia C; Espinosa Perez Georgina

来源：Tetrahedron Letters, 2015, 56(44): 5977-5979.

DOI：10.1016/j.tetlet.2015.09.005

• Resveratrol
• Sonogashira
• (E)-3 ',4,5 '-trihydroxy-stilbene
• Reduction diarylalkynes
• Aryl halides coupling with terminal alkynes

Resveratrol was synthesized in a 4-step synthesis using a simple Sonogashira type reaction with 93% yield using commercially available 3,5-dimethoxy-1-ethynyl-benzene and 4-iodoanisole, followed by reduction, isomerization, and deprotection and with an overall yield of 63%.

• 出版日期2015-10-28