Association Between Echocardiographic Parameters and Brain Natriuretic Peptide Levels in Treated Hypertensive Patients

作者：Masugata Hisashi^*; Senda Shoichi; Murao Koji; Okuyama Hiroyuki; Inukai Michio; Hosomi Naohisa; Iwado Yasuyoshi; Noma Takahisa; Kohno Masakazu; Goda Fuminori

来源：Clinical and Experimental Hypertension, 2011, 33(3): 187-191.

DOI：10.3109/10641963.2010.531851

• plasma brain natriuteric peptide
• hypertension
• echocardiography
• left ventricular hypertrophy
• left ventricular diastolic dysfunction

We examined which echocardiographic parameter correlated best with plasma brain natriuteric peptide (BNP) levels in treated hypertensive patients. Enrolled in the study were 122 treated hypertensive patients (70 +/- 9 y). The left ventricular mass index and left atrial dimension (LAD) were measured using echocardiography as indexes of left ventricular hypertrophy and left atrial enlargement, respectively. Among all the echocardiographic parameters, LAD correlated best with BNP (r = 0.343, p < 0.001). Stepwise regression analysis showed that LAD (beta coefficient = 0.513, p < 0.001) was independently associated with BNP. Left atrial enlargement, rather than left ventricular hypertrophy, may be clinically useful for predicting elevated BNP levels in treated hypertensive patients.

• 出版日期2011