An Efficient, Regioselective, Versatile Synthesis of N-Fused 2-and 3-Aminoimidazoles via Ugi-Type Multicomponent Reaction Mediated by Zirconium(IV) Chloride in Polyethylene Glycol-400

作者：Guchhait Sankar K^*; Madaan Chetna

来源：Synlett, 2009, 2009(4): 628-632.

DOI：10.1055/s-0028-1087915

• multicomponent reaction
• regioselective synthesis
• N-heterocycles
• zirconium(IV) chloride
• polyethylene glycol

An Ugi-type multicomponent reaction of heterocyclic amidines with aldehydes and isocyanides catalyzed by zirconium(IV)chloride in PEG-400 was developed. The protocol offers the rapid, environment friendly, regioselective and versatile synthesis of medicinally important N-fused 2- and 3-aminoimidazoles in good to high yields. The combination of catalyst and solvent, that was judiciously explored, was crucial for regioselectivity and versatility of the method.

• 出版日期2009-3-3