Association Between Joint Hypermobility Syndrome and Panic Disorder: A Case-Control Study

作者：Garcia Campayo Javier; Asso Elena; Alda Marta; Maria Andres Eva; Sobradiel Natalia

来源：Psychosomatics, 2010, 51(1): 55-61.

DOI：10.1176/appi.psy.51.1.55

Background: A significant association between joint hypermobility syndrome (JHS) and panic disorder was observed in a sample of rheumatology outpatients. Objective: The aim of this study was to assess whether JHS is more frequent in panic-disorder than in control subjects. Method: The authors conducted a case-control study comparing 55 untreated patients with panic disorder and three matched-control groups: psychiatric patients, fibromyalgia patients, and healthy persons. Results: JHS was more frequent among panic-disorder than among psychiatric patients, the healthy group, or the fibromyalgia group. In the panic-disorder group, there was a significant correlation between severity of JHS and anxiety. Conclusion: The strong association between JHS and panic disorder points to a genetic association. There is also a possibility that JHS and mitral valve prolapse, another condition frequently associated with panic disorder, share a common pathophysiological mechanism. (Psychosomatics 2010; 51: 55-61)

• 出版日期2010-2