A unique display of toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in non-Han Chinese Hani population

作者：Zheng, B.; Wei, C.; Shou, T.; Li, Q.; Yang, M.; Yi, L.; Zhou, R.; Shao, J.; Xiao, C.^*

来源：International Journal of Immunogenetics, 2010, 37(1): 43-46.

DOI：10.1111/j.1744-313X.2009.00878.x

• ESSENTIAL-HYPERTENSION
• GENE POLYMORPHISMS
• TLR4 MUTATIONS
• SUSCEPTIBILITY
• ASSOCIATION
• INFECTION
• CD14
• LIPOPOLYSACCHARIDE
• HYPORESPONSIVENESS
• RELEVANCE

P>The toll-like receptor 4 (TLR4) polymorphisms, Asp299Gly and Thr399Ile, were investigated with PCR-RFLP and DNA sequencing methods in 938 and 980 individuals from the Yunnan Hani ethnic minority and the majority Han population, respectively. Six heterozygotes for both Asp299Gly and Thr399Ile were detected in the Hani, a polymorphism frequency of 0.6397%, whereas no variants were found amongst the Han.

• 出版日期2010-2
• 单位昆明医科大学; 云南大学; 红河哈尼族彝族自治州第二人民医院