Pathogenicity of highly pathogenic avian influenza virus in mammals

作者：de Wit Emmie; Kawaoka Yoshihiro; de Jong Menno D; Fouchier Ron A M^*

来源：Vaccine, 2008, 26: D54-D58.

DOI：10.1016/j.vaccine.2008.07.072

• Influenza A virus
• Pathogenicity
• HPAI

In recent years, there has been an increase in outbreaks of highly pathogenic avian influenza (HPAI) in poultry. Occasionally, these outbreaks have resulted in transmission of influenza viruses to humans and other mammals, with symptoms ranging from conjunctivitis to pneumonia and death. Here the current, knowledge of the determinants of pathogenicity of HPAI viruses in mammals is summarized. It is becoming apparent that common mechanisms exist across influenza A virus strains and subtypes, through which influenza viruses adapt to mammals and gain or loose pathogenicity.

• 出版日期2008-9-12
• 单位河北医科大学