A Quick, Simple and Clean Synthesis of Spiro (indoline-3,4 '-pyrazolo[4 ',3 ':5,6]pyrido[2,3-d]pyrimidines) in Water through a Novel One-Pot Multicomponent Reaction

作者：Kalita Subarna Jyoti; Das Bidyut; Deka Dibakar Chandra^*

来源：ChemistrySelect, 2017, 2(20): 5701-5706.

DOI：10.1002/slct.201701131

• Aqueous medium
• Green Chemistry
• Multicomponent reactions (MCRs)
• para-Toluene sulfonic acid monohydrate (p-TSA. H2O)
• Spiro compounds

A novel and general protocol for quick, simple and efficient synthesis of spiro[indoline-3,4'-pyrazolo[4',3':5,6] pyrido[2,3-d] pyrimidines] via one-pot three component reactions of isatins, 5-aminopyrazoles and 6-aminouracils or 2,6-diaminopyrimidin-4-one in water catalyzed by para-toluene sulfonic acid monohydrate (p-TSA.H2O) under mild reaction conditions has been described. Use of water as the solvent system, application of mild and cost-effective solid p-TSA.H2O as organocatalyst, high yield in short reaction time, simple purification process with no chromatographic technique and operational simplicity make the protocol highly attractive.

• 出版日期2017-7-11