An assessment of neurocognitive speed in relation to frailty

作者：Rolfson Darryl B^*; Wilcock Gordon; Mitnitski Arnold; King Elizabeth; de Jager Celeste A; Rockwood Kenneth; Fallah Nader; Searle Samuel D

来源：Age and Ageing, 2013, 42(2): 191-196.

DOI：10.1093/ageing/afs185

• frailty
• aged
• measurement
• neurocognitive speed
• cognitive impairment older people

Objectives: to evaluate the relationship between neurocognitive speed (NCS) and frailty; to consider how this relationship is affected by how frailty is operationalised. %26lt;br%26gt;Design: secondary analysis of the baseline cohort of the Oxford Project To Investigate Memory and Aging (OPTIMA), a longitudinal observational cohort. %26lt;br%26gt;Subjects: of 388 participants who underwent a comprehensive intake assessment followed by an annual follow-up for at least 3 years, data on all measures were available on 164 people. %26lt;br%26gt;Measurements: NCS was defined as a combined score of %26lt;18 on the pattern comparison test (%26lt;11 is abnormal) and letter comparison test (%26lt;7 is abnormal). Frailty was defined from a modified Phenotype model, the Edmonton Frailty Scales (EFS) and a frailty index (FI); the latter two were adapted here to exclude cognitive measures. %26lt;br%26gt;Results: in multivariate logistic (NCS as %26lt; or %26gt;= 18) and linear regression (NCS as continuous variable), only the FI (OR = 0.87) was significant (P %26lt; 0.05). When all frailty measures were induded in the multivariate analysis only, FI (OR = 0.88) was significant (P %26lt; 0.05). Mini-mental Status Examination remained significantly related to NCS throughout all analysis. %26lt;br%26gt;Conclusion: NCS slows with increasing frailty as shown with the FL

• 出版日期2013-3