Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial

作者：ten Brinke, Lisanne F.; Bolandzadeh, Niousha; Nagamatsu, Lindsay S.; Hsu, Chun Liang; Davis, Jennifer C.; Miran-Khan, Karim; Liu-Ambrose, Teresa^*

来源：British Journal of Sports Medicine, 2015, 49(4): 248-U63.

DOI：10.1136/bjsports-2013-093184

• RESISTANCE EXERCISE
• PHYSICAL-ACTIVITY
• TALK TEST
• PLASTICITY
• BRAIN
• FITNESS
• ATROPHY
• MEMORY
• ADULTS

Background Mild cognitive impairment (MCI) is a well-recognised risk factor for dementia and represents a vital opportunity for intervening. Exercise is a promising strategy for combating cognitive decline by improving brain structure and function. Specifically, aerobic training (AT) improved spatial memory and hippocampal volume in healthy community-dwelling older adults. In older women with probable MCI, we previously demonstrated that resistance training (RT) and AT improved memory. In this secondary analysis, we investigated: (1) the effect of RT and AT on hippocampal volume and (2) the association between change in hippocampal volume and change in memory. @@@ Methods 86 women aged 70-80 years with probable MCI were randomly assigned to a 6-month, twice-weekly programme of: (1) AT, (2) RT or (3) balance and tone training (BAT; ie, control). At baseline and trial completion, participants performed a 3T MRI scan to determine hippocampal volume. Verbal memory and learning were assessed by Rey's Auditory Verbal Learning Test. @@@ Results Compared with the BAT group, AT significantly improved left, right and total hippocampal volumes (p <= 0.03). After accounting for baseline cognitive function and experimental group, increased left hippocampal volume was independently associated with reduced verbal memory and learning performance as indexed by loss after interference (r=0.42, p=0.03). @@@ Conclusions Aerobic training significantly increased hippocampal volume in older women with probable MCI. More research is needed to ascertain the relevance of exercise-induced changes in hippocampal volume on memory performance in older adults with MCI.

• 出版日期2015-2