A genetic link between type 2 diabetes and prostate cancer - Commentary

作者：Frayling T M^*; Colhoun H; Florez J C

来源：Diabetologia, 2008, 51(10): 1757-1760.

DOI：10.1007/s00125-008-1114-9

• epidemiology
• genes
• genome-wide association study
• pleiotropy
• prostate cancer
• transcription factors
• type 2 diabetes

Epidemiological studies suggest that men with type 2 diabetes are less likely than non-diabetic men to develop prostate cancer. The cause of this association is not known. Recent genetic studies have highlighted a potential genetic link between the two diseases. Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. Other, separate, studies have identified different variants in the JAZF1 gene, one associated with type 2 diabetes, another associated with prostate cancer. These findings are unlikely to completely explain the epidemiological association between the two diseases but they provide new insight into a possible direct causal link, rather than one that is confounded or biased in some way.

• 出版日期2008-10