MicroRNA-140-3p expression level is an independent prognostic factor in NSCLC

作者：Qu, Yimei; Zhou, Lei; Li, Liangliang; Liu, Penghui; Jiao, Shunchang^*

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(8): 8565-8569.

• MiR-140-3p
• NSCLC
• prognosis

Objective: The aim of the present study was to explore the clinical significance of microRNA-140-3p expression in NSCLC. Methods: The expression patterns of miR-140-3p in 224 pairs of human lung cancer tissues and normal tissues were analyzed using qRT-PCR. The relationship between clinicopathologic characteristics and miR-140-3p was analyzed by chi-square test. Survival curves were assessed by the Kaplan-Meier method and log-rank tests was used to examine the differences. The Cox proportional hazard regression model was used to analyze the risk factors for NSCLC. Results: The expression of miR-140-3p in NSCLC tissues was lower than that in the adjacent non-tumor tissues. The down-regulation of miR-140-3p was significantly associated with lymphatic invasion (P = 0.001), distant metastasis (P < 0.001), TNM stage (P = 0.002), and tumor grade (P = 0.025). Kaplan-Meier analy-sis with the log-rank test showed that low miR-140-3p expression had a significant impact on OS (P < 0.001). Furthermore, Multivariate Cox analysis indicated that miR-140-3p expression was an independent prognostic factor for OS in patients with NSCLC. Conclusion: The miR-140-3p may be a potential prognostic bio-marker of NSCLC.

• 出版日期2016
• 单位中国人民解放军总医院; 首都医科大学; 中国人民解放军第三〇九医院