Novel Three-Component Route to Diastereoselective Synthesis of Trisubstituted Vinylphosphonates Using Phosphites, Acetylenic Esters, and Aroyl Chlorides

作者：Rostamnia Sadegh; Alizadeh Abdolah^*; Zhu Long Guan

来源：Journal of Combinatorial Chemistry, 2009, 11(1): 143-145.

DOI：10.1021/cc800128j

Trisubstituted vinylphosphonates have been prepared via three-component reaction using phosphites, acetylenic esters, and aroyl chlorides in good yields. A variety of phosphites, activated acetylenes, and aroyl chlorides have been successfully employed in these reactions. In addition, three-component synthesis of vinylphosphonate provides exclusive E-olefin stereochemistry.

• 出版日期2009-2
• 单位浙江大学