MRI and C-11 acetate PET/CT for prediction of regional lymph node metastasis in newly diagnosed prostate cancer

作者：von Below Catrin; Was**erg Cecilia; Grzegorek Rafael; Kullberg Joel; Gestblom Charlotta; Sorensen Jens; Walden Mauritz; Ahlstrom Hakan^*

来源：Radiology and Oncology, 2018, 52(1): 90-97.

DOI：10.2478/raon-2018-0001

• prostatic neoplasm
• lymph nodes
• lymph node excision
• diffusion magnetic resonance imaging
• positron-emission tomography

Background. The aim of the study was to examine the value of quantitative and qualitative MRI and C-11 acetate PET/CT parameters in predicting regional lymph node (LN) metastasis of newly diagnosed prostate cancer (PCa). Patients and methods.
Patients with intermediate (n = 6) and high risk (n = 47) PCa underwent 3T MRI (40 patients) and 11C acetate PET/CT (53 patients) before extended pelvic LN dissection. For each patient the visually most suspicious LN was assessed for mean apparent diffusion coefficient (ADCmean), maximal standardized uptake value (SUVmax), size and shape and the primary tumour for T stage on MRI and ADCmean and SUVmax in the index lesion. The variables were analysed in simple and multiple logistic regression analysis.
Results. All variables, except ADCmean and SUVmax of the primary tumor, were independent predictors of LN metastasis. In multiple logistic regression analysis the best model was ADCmean in combintion with MRI T-stage where both were independent predictors of LN metastasis, this combination had an AUC of 0.81 which was higher than the AUC of 0.65 for LN ADCmean alone and the AUC of 0.69 for MRI T-stage alone.
Conclusions. Several quantitative and qualitative imaging parameters are predictive of regional LN

• 出版日期2018-3