Facile and Rapid Synthesis of 5-Substituted 1H-Tetrazoles VIA a Multicomponent Domino Reaction Using Nickel(II) Oxide Nanoparticles as Catalyst

作者：Safaei Ghomi J^*; Paymard Samani S

来源：Chemistry of Heterocyclic Compounds, 2015, 50(11): 1567-1574.

DOI：10.1007/s10593-014-1625-x

• NiO nanoparticles
• 2-(1H-tetrazol-5-yl)acrylonitrile
• 1,3-dipolar cycloaddition
• Knoevenagel condensation

2-(1H-Tetrazol-5-yl)acrylonitrile derivatives were synthesized through multicomponent domino Knoevenagel condensation/1,3-dipolar cycloaddition reaction of carbonyl compounds, malononitrile, and sodium azide in the presence of NiO nanoparticles as a highly efficient catalyst. This method has the advantage of very short reaction times, high yields, simple methodology, and easy work-up. The catalyst can be recovered and reused while maintaining good yields.

• 出版日期2015-2