Azacoccones A - E, five new aza-epicoccone derivatives from Aspergillus flavipes

作者：Zou, Shupeng; Wang, Zhongbo; Wang, Jing; Wei, Guangzheng; Wang, Wenjing; Zang, Yi; Zeng, Fanrong; Chen, Keliang; Liu, Junjun; Wang, Jianping; Luo, Zengwei; Xue, Yongbo; Zhu, Hucheng; Yin, Chunping^*; Chen, Chunmei^*; Zhang, Yonghui^*

来源：Fitoterapia, 2018, 124: 127-131.

DOI：10.1016/j.fitote.2017.10.022

• Azacoccones A-E
• Aza-epicoccone derivatives
• Aspergillus flavipes
• Free radical scavenging activities

Azacoccones A-E (1-5), five new aza-epicoccone derivatives, were isolated from the culture of Aspergillus flavipes. Their structures were determined by extensive NMR spectroscopic analyses and the absolute configuration of 5 was determined by electronic circular dichroism (ECD) calculation. Compounds 1-5 are proposed to be generated via a Pictet-Spengler reaction-based biosynthetic route starting from the precursor flavipin. Pictet-Spengler reaction is rarely found in the fungal kingdom, which indicated the distinctive nature of 1-5. Compounds 3 and 5 exhibit significant free radical scavenging activities with IC50 values of 4.0 and 2.4 mu g/mL, respectively, which are better than the positive control trolox (4.55 mu g/mL).

• 出版日期2018-1
• 单位华中科技大学