alpha-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion

作者：Yamakado Hodaka; Moriwaki Yasuhiro; Yamasaki Nobuyuki; Miyakawa Tsuyoshi; Kurisu Junko; Uemura Kengo; Inoue Haruhisa; Takahashi Makio^*; Takahashi Ryosuke

来源：Neuroscience Research, 2012, 73(2): 173-177.

DOI：10.1016/j.neures.2012.03.010

• Parkinson's disease
• alpha-Synuclein
• PARK4
• BAC transgenic mouse
• Serotonin transporter
• Decreased anxiety

alpha-Synuclein (alpha-syn), the main component of Lewy bodies, was identified as a genetic risk factor for idiopathic Parkinson's disease (PD). As a model for PD, we generated human alpha-syn bacterial artificial chromosome transgenic mice (BAC tg mice) harboring the entire human alpha-syn gene and its gene expression regulatory regions. The alpha-syn BAC tg mice manifested decreased anxiety-like behaviors which may reflect non-motor symptoms of early PD, and they exhibited increased SERT expression that may be responsible for decreased anxiety-like behaviors. Our alpha-syn BAC tg mice could be a valuable tool to evaluate alpha-syn gene dosage effects in vivo.

• 出版日期2012-6