alpha-thalassemia among tribal populations of Eastern India

作者：Sen R^*; Chakrabarti S; Sengupta B; De M; Haldar A; Poddar S; Gajra B; Talukder G; Sengupta S

来源：Hemoglobin, 2005, 29(4): 277-280.

DOI：10.1080/03630260500310711

• alpha-thalassemia (thal)
• tribal screening

Five hundred and thirteen unrelated subjects belonging to various tribes of West Bengal, Arunachal Pradesh and Assam in Eastern India, were screened for the presence of alpha-thalassemia (thal) gene deletion(s) as a possible cause of unexplained anemia (Hb< 11 g/dL and/or MCH < 28 pg, MCV < 78 fL). As reported earlier, beta-globin gene mutant alleles were found with a frequency of up to 20% in some tribes. In the present study, alpha-globin gene deletion alleles were found in 18% of subjects from West Bengal, 3.9% from Arunachal Pradesh and 3.84% from Assam tribesmen. Coexistence of alpha- and beta-globin gene abnormalities was observed in up to 18% of some tribal groups. The high inbreeding rate and lack of appropriate medical care make these populations particularly vulnerable.

• 出版日期2005
• 单位河北医科大学