Non-symmetrically substituted N-heterocyclic carbene-Ag(I) complexes of benzimidazol-2-ylidenes: Synthesis, crystal structures, anticancer activity and transmetallation studies

作者：Haque Rosenani A^*; Ghdhayeb Mohammed Z; Budagumpi Srinivasa; Salman Abbas Washeel; Ahamed Mohamed B Khadeer; Majid Amin Malik Shah Abdul

来源：Inorganica Chimica Acta, 2013, 394: 519-525.

DOI：10.1016/j.ica.2012.09.013

• Anticancer agent
• Ag(I)-carbene complex
• N-Heterocyclic carbene
• Transmetallation
• X-ray diffraction

Non-symmetrically substituted benzimidazolium salts (1 and 2) having bromide counterion undergo metallation with Ag2O at stiochiometric ratio, giving mononuclear bis-carbene Ag(I) complexes (3 and 4), active as anticancer agents against Human Colorectal (HCT 116) cell lines. Both the complexes provide good activity (IC50 = 13.9 mu M for 3 and 14.6 mu M for 4) in the anticancer studies and so distinctly better than the ligand precursors (IC50 = 119.3 mu M for 1, and 70.0 mu M for 2). The molecular structure of Ag complexes 3 and 4 is elucidated by X-ray diffraction studies. The Pd(II)- and Au(I)-NHC complexes (5 and 6) were synthesized from 4 via the technique of transmetallation. However, attempts to produce transmetallated complexes using 3 were unsuccessful.

• 出版日期2013-1-1