科研之友
微信
新浪微博
Facebook
分享链接
摘要
Subjects The study sample numbered 148 children (80 intervention group, 68 control group) recruited from a larger randomized controlled trial that had originally enrolled 1062 infants from well-baby clinics in Turku, Finland from 1990 to 1992. The dental sub-study randomly sampled from the 881 children who remained in the main study at age 3 years. After follow-up visits at ages 6, 9, 12, and 16 years, 88 children (59%) remained in the dental sub-study (46 intervention group, 42 control group). The salivary flow rate in the study population increased with age and was 1.6 ml/min (SD 0.7 ml/min) at age 16 years. Dental caries was observed during at least one study visit in 130 of the 148 participants. Caries prevalence at age 16 years was not reported. Key Exposure/Study Factor In the Special Turku Risk Factor Intervention Project (STRIP), infants and their families were randomly assigned at age 7 months either to an intervention group who received individualized dietary counseling that encouraged limiting dietary cholesterol to less than 200 mg/day and achieving fat intake at 30% to 35% of daily energy with a 1: 2 ratio of saturated to mono and polyunsaturated fat or to a control group who received basic health education. 1 Intervention group families received counseling every 1 to 3 months to age 2 years and semiannually to age 20 years; control group health education occurred semiannually through age 6 years and annually to age 20 years. Main Outcome Measure At ages 6, 9, 12, and 16 years, calibrated technicians masked to intervention grouping collected saliva samples. In the primary analysis, the authors compared two variables between intervention and control groups: (1) Salivary flow rate (ml/min), measured by collecting 4 ml of stimulated whole saliva after 1 min of chewing paraffin wax and at least 1 hour of fasting, and (2) salivary buffering capacity, based on color changes observed visually on commercial test strips and classified as good (pH >= 6.0), normal (pH 4.5 to 5.5), or low (pH <= 4.0). Main Results At each age evaluated, salivary flow rate, on average, was 0.1-0.2 ml/min greater among intervention group children than among children in the control group (p = 0.04 from repeated-measures generalized linear model). A greater percentage of children were classified as having "good" salivary buffering capacity in the intervention group than in the control group (p < 0.01 from repeated-measures generalized linear model). The authors also stated that the dietary intervention produced no difference in dental health between the study groups but did not quantify this finding. Conclusions Repeated, individualized dietary counseling focusing on fat and cholesterol intake from an early age may increase salivary flow rate and buffering capacity. At this time, there is insufficient evidence that dietary modification of this particular nature leads to caries prevention.
- 出版日期2014-9
